ABSTRACT
Objective: to evaluate the efficacy of the combination therapy of mometasone and pimecrolimus in the treatment of vitiligo in children
Methods: in this double-blind randomized controlled trial, 50 patients were enrolled. Based on the planned treatment protocol, three lesions with approximately identical size at similar anatomic sites were selected in each patient. Lesions were divided to three groups: pimecrolimus cream 1 % [twice a day], mometasone furoate ointment 0.1 % [every night], and combined therapy group [pimecrolimus twice a day on weekdays and mometasone every night on weekends], all being applied for three months. They were followed up for three months
Results: forty patients [with 46% of cases being male] with a mean age of 10.6 years completed the study. There was no significant difference in response rate between three groups at the end of the treatment
Conclusion: our study results did not demonstrate significant difference in the response rate and adverse effects between combined treatment group and either alone
ABSTRACT
Objective To evaluate the efficacy of combined, cantharidin and cryotherapy versus placebo and cryotherapy in common warts
Methods This was a double-blind clinical trial conducted on 110 patients. Lesions in both groups underwent cryotherapy followed by topical solution of cantharidin and flexible collodion in case and control groups, respectively. Participants were assessed based on cure rate, adverse effects and recurrence rate
Results Complete cure was achieved in cantharidin group after 3.4 treatment sessions vs. 4.7 in control group. In cantharidin group, higher prevalence of hyperpigmentation was reported but incidence of atrophic scar was lower than control group. Recurrence rate in both groups was not statistically meaningful
Conclusion Cantharidin can be recommended as a safe and effective adjunct treatment in children and patients where other treatment modalities are contraindicated
ABSTRACT
Objective To evaluate the efficacy of niosomal dapsone gel and intralesional meglumine antimoniate with cryotherapy and intralesional meglumine antimoniate in cutaneous leishmaniasis
Methods This was a randomized clinical trial with 73 participants that were divided into two groups including, case group [weekly intralesional meglumine antimoniate and twice a day niosomal dapsone gel] and control group [weekly intralesional meglumine antimoniate with biweekly cryotherapy]. The treatment course continued until 16 weeks or complete cure, whatever occurred earlier and participants were followed up in 4th, 8th, 12th and 16th weeks of the treatment
Results Overall, 68 patients [33 males and 35 female] completed the study. Age, sex, size and duration of the lesions were not statistically different between two groups. At the end of the study, 82.9% of patients in case group showed complete response
Conclusion Niosomal dapsone gel has promising results with fewer adverse effects, so, it can be used as an alternative treatment modality, especially in children and patients with contraindication of systemic drugs
ABSTRACT
To determine the association between the severity of AD and serum level of 25[OH] vitamin D in Kerman, a desert area in southeast of Iran, that was performed for the first time in Iran. In this cross-sectional study 57 AD subjects and 19 healthy children under the age of 18 years old were enrolled. The serum levels of 25[OH] vitamin D were measured in the both groups. The severity of AD was evaluated according to SCORAD. According to our study, there was a significant association between serum level of vitamin D and severity of AD especially in moderate and severe forms of AD [p<0.001]. Our study revealed vitamin D deficiency in AD patients, thus, it is recommended to take vitamin D supplementation in AD patient. Additional research is needed in order to evaluate dysfunction of vitamin D receptor in AD patients